Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma Based on Integration Analysis of TCGA/ICGC Databases and Single-cell Sequencing.
Zupin HuangZhuokai LiXinliang LvWei TanPublished in: Recent patents on anti-cancer drug discovery (2024)
Inflammatory factors CCL7, GPR132, ITGB8, PTAFR, SELL, and VIP influence the inflammatory cascade response in HCC epithelial cells, and their expression correlates with the survival prognosis of HCC patients. Interfering with VIP expression effectively suppresses proliferation, migration, and invasion of HCC cells, as well as inhibiting the occurrence of inflammatory cascade reactions, thus slowing down the progression of hepatocellular carcinoma. Furthermore, compounds NADH and Deferoxamine have the potential to target and bind to the inflammatory protein VIP, highlighting their relevance in potential HCC treatment.
Keyphrases
- single cell
- oxidative stress
- poor prognosis
- signaling pathway
- end stage renal disease
- ejection fraction
- binding protein
- chronic kidney disease
- peritoneal dialysis
- rna seq
- high throughput
- long non coding rna
- fatty acid
- small molecule
- big data
- climate change
- cell death
- artificial intelligence
- replacement therapy
- liver fibrosis