p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy.
Kaixin YangYinan XiaoLinghui ZhongWenyang ZhangPeng WangYaru RenLei ShiPublished in: Cancer gene therapy (2023)
Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through various mechanisms such as transcription, translation, protein modification and RNA-protein complexes. LncRNA dysregulation is frequently associated with a variety of biological functions and human diseases including cancer. The p53 network is a key tumor-suppressive mechanism that transcriptionally activates target genes to suppress cellular proliferation in human malignancies. Recent research indicates that lncRNAs play an important role in the p53 signaling pathway. In this review, we summarize the current knowledge of lncRNAs in p53-relevant functions and provide an overview of how these altered lncRNAs contribute to tumor initiation and progression. We also discuss the association between lncRNA and up- or downstream genes of p53. These findings imply that lncRNAs can help identify cellular vulnerabilities that may prove to be promising potential biomarkers and therapeutic targets for cancer treatment.
Keyphrases
- genome wide identification
- genome wide analysis
- transcription factor
- long non coding rna
- signaling pathway
- network analysis
- endothelial cells
- genome wide
- healthcare
- poor prognosis
- epithelial mesenchymal transition
- pluripotent stem cells
- long noncoding rna
- protein protein
- squamous cell carcinoma
- mesenchymal stem cells
- binding protein
- stem cells
- oxidative stress
- endoplasmic reticulum stress
- small molecule
- lymph node metastasis