Association of Clinical Relapses With Disease Outcomes in Multiple Sclerosis Patients Older Than 50 Years.
Steffen PfeufferStephanie WolffDerya AslanLeoni RolfesMelanie KorsenMarc PawlitzkiPhilipp AlbrechtJoachim HavlaHagen B HuttnerChristoph KleinschnitzSven Guenther MeuthRefik PulTobias RuckPublished in: Neurology (2024)
A relapse-suggesting underlying active disease-in PwMS older than 50 years was associated with continued disease activity and increased risk of PIRA. Presence of CVRF and absence of DMT at baseline appeared as risk factors of disadvantageous disease courses. An escalation of DMT switch was associated with stable over active but not progressive disease.
Keyphrases
- multiple sclerosis
- disease activity
- risk factors
- systemic lupus erythematosus
- end stage renal disease
- newly diagnosed
- randomized controlled trial
- type diabetes
- ankylosing spondylitis
- ejection fraction
- metabolic syndrome
- rheumatoid arthritis patients
- middle aged
- peritoneal dialysis
- community dwelling
- insulin resistance