The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation.

Erik LadewigFlavia MicheliniKomal JhaveriHatice Ulku OsmanbeyogluJavier CarmonaLauren FairchildAdler G ZunigaAmaia Arruabarrena-Aristorena Emiliano CoccoRyan BlawskiSrushti KittaneYuhan ZhangMirna SallakuLaura BaldinoVasilis Hristidis Sarat ChandarlapatyOmar Abdel-WahabChristina S Leslie Maurizio Scaltriti Eneda Toska

Published in: Cancer research (2022)

Transcriptomic analysis reveals a key role for the PI3K pathway in regulating RNA splicing, uncovering new mechanisms by which PI3K regulates proliferation and metabolism in breast cancer. See related commentary by Claridge and Hopkins, p. 2216.

Keyphrases

gene expression
single cell
high glucose
diabetic rats
signaling pathway
drug induced
transcription factor
rna seq
oxidative stress
nucleic acid