Christina S Leslie (Christina Leslie, C S Leslie)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 92

Top Venues

Nature methods

Nature genetics

Nature

Nature communications

Memorial Sloan-Kettering Cancer Center

University of California Berkeley (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Memorial Sloan-Kettering Cancer Center Jul 01 2007

United States

Associate Member :: Computational and Systems Biology Program

Education History

University of California Berkeley

United States

PHD :: Mathematics

Publications

Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
Zakieh Tayyebi, Allison R Pine, Christina S Leslie
Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace. Nature methods (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods (2024)
Zakieh Tayyebi, Allison R Pine, Christina S Leslie
Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace. Nature methods 21 (6) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Zakieh Tayyebi, Allison R Pine, Christina S Leslie
Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace. Nature methods 21 (6) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
Zakieh Tayyebi, Allison R Pine, Christina S Leslie
Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace. Nature methods 21 (6) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics (2024)
Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Matthew Lange, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Elisa De Stanchina, Juliet Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity. bioRxiv : the preprint server for biology (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Matthew Lange, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Elisa De Stanchina, Juliet Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity. bioRxiv : the preprint server for biology (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature (2024)
David Yao, Josh Tycko, Jin Woo Oh, Lexi R Bounds, Sager J Gosai, Lazaros Lataniotis, Ava Mackay Smith, Benjamin R Doughty, Aditi K Narayanan, Henri Schmidt, Tania Guerrero-Altamirano, Keith Siklenka, Katherine Guo, Alexander D White, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunhai Luo, Galip Gürkan Yardımcı, Ryan Tewhey, Anshul Kundaje, William J Greenleaf, Pardis C Sabeti, Christina S Leslie, Yuri Pritykin, Jill E Moore, Michael A Beer, Charles A Gersbach, Timothy E Reddy, Yin Shen, Jesse M Engreitz, Michael C Bassik, Steven K Reilly
Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods 21 (4) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Matthew Lange, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Elisa De Stanchina, Juliet Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity. bioRxiv : the preprint server for biology (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Zakieh Tayyebi, Allison R Pine, Christina S Leslie
Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace. Nature methods 21 (6) (2024)
Zakieh Tayyebi, Allison R Pine, Christina S Leslie
Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace. Nature methods 21 (6) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Author Correction: Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics (2024)
Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Matthew Lange, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Elisa De Stanchina, Juliet Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity. bioRxiv : the preprint server for biology (2024)
Sneha Mitra, Rohan Malik, Wilfred Wong, Afsana Rahman, Alexander J Hartemink, Yuri Pritykin, Kushal K Dey, Christina S Leslie
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature genetics 56 (4) (2024)
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M Walsh, Kelly A Aromolaran, Alberto J Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J Sevilla, Peter A Goldstein, Joshua Levitz, Christina S Leslie, Richard P Koche, Lorenz Studer
An epigenetic barrier sets the timing of human neuronal maturation. Nature 626 (8000) (2024)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Andreas R Gschwind, Kristy S Mualim, Alireza Karbalayghareh, Maya U Sheth, Kushal K Dey, Evelyn Jagoda, Ramil N Nurtdinov, Wang Xi, Anthony S Tan, Hank Jones, X Rosa Ma, David Yao, Joseph Nasser, Žiga Avsec, Benjamin T James, Muhammad Saad Shamim, Neva C Durand, Suhas S P Rao, Ragini Mahajan, Benjamin R Doughty, Kalina Andreeva, Jacob C Ulirsch, Kaili Fan, Elizabeth M Perez, Tri C Nguyen, David R Kelley, Hilary K Finucane, Jill E Moore, Nishigandha Phalke, Manolis Kellis, Michael C Bassik, Alkes L Price, Michael A Beer, Roderic Guigo, John A Stamatoyannopoulos, Erez Lieberman Aiden, William J Greenleaf, Christina S Leslie, Lars M Steinmetz, Anshul Kundaje, Jesse M Engreitz
An encyclopedia of enhancer-gene regulatory interactions in the human genome. bioRxiv : the preprint server for biology (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Ignas Masilionis, Ronan Chaligné, Elisa De Stanchina, Juliet Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers
ERG-driven prostate cancer emerges from basal-luminal hybrid cells. bioRxiv : the preprint server for biology (2023)
Rui Yang, Arnav Das, Vianne R Gao, Alireza Karbalayghareh, William S Noble, Jeffery A Bilmes, Christina S Leslie
Epiphany: predicting Hi-C contact maps from 1D epigenomic signals. Genome biology 24 (1) (2023)
Melanie H Smith, Vianne R Gao, Preethi K Periyakoil, Alejandro Kochen, Edward F DiCarlo, Susan M Goodman, Thomas M Norman, Laura T Donlin, Christina S Leslie, Alexander Y Rudensky
Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis. Nature immunology (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Ashlesha Odak, Han Yuan, Judith Feucht, Vito Adrian Cantu, Jorge Mansilla-Soto, Friederike Kogel, Justin Eyquem, John K Everett, Frederic D Bushman, Christina S Leslie, Michel Sadelain
Novel extragenic genomic safe harbors for precise therapeutic T cell engineering. Blood (2023)
Ashlesha Odak, Han Yuan, Judith Feucht, Vito Adrian Cantu, Jorge Mansilla-Soto, Friederike Kogel, Justin Eyquem, John K Everett, Frederic D Bushman, Christina S Leslie, Michel Sadelain
Novel extragenic genomic safe harbors for precise therapeutic T cell engineering. Blood (2023)
Vianne R Gao, Rui Yang, Arnav Das, Renhe Luo, Hanzhi Luo, Dylan R McNally, Ioannis Karagiannidis, Martín A Rivas, Zhong-Min Wang, Darko Barisic, Alireza Karbalayghareh, Wilfred Wong, Yingqian Ada Zhan, Christopher R Chin, William Noble, Jeff A Bilmes, Effie Apostolou, Michael Gregory Kharas, Wendy Béguelin, Aaron D Viny, Danwei Huangfu, Alexander Y Rudensky, Ari M Melnick, Christina S Leslie
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility. bioRxiv : the preprint server for biology (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Allison R Pine, Stefano M Cirigliano, Richa Singhania, James G Nicholson, Barbara Da Silva, Christina S Leslie, Howard A Fine
Microenvironment-driven dynamic chromatin changes in glioblastoma recapitulate early neural development at single-cell resolution. Cancer research (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Dapeng Yang, Hyunwoo Cho, Zakieh Tayyebi, Abhijit Shukla, Renhe Luo, Gary Dixon, Valeria Ursu, Stephanie Stransky, Daniel M Tremmel, Sara D Sackett, Richard P Koche, Samuel J Kaplan, Qing V Li, Jiwoon Park, Zengrong Zhu, Bess P Rosen, Julian Pulecio, Zhong-Dong Shi, Yaron Bram, Robert E Schwartz, Jon S Odorico, Simone Sidoli, Christopher V Wright, Christina S Leslie, Danwei Huangfu
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Nature cell biology 24 (7) (2022)
Yuchen Xie, Merve Sahin, Sonali Sinha, Yufeng Wang, Amrita M Nargund, Yang Lyu, Song Han, Yiyu Dong, James J Hsieh, Christina S Leslie, Emily H Cheng
SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes. Nature cancer 3 (2) (2022)
Briana G Nixon, Chun Chou, Chirag Krishna, Saïda Dadi, Adam O Michel, Andrew E Cornish, Emily R Kansler, Mytrang H Do, Xinxin Wang, Kristelle J Capistrano, Alexander Y Rudensky, Christina S Leslie, Ming O Li
Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity. Science immunology 7 (70) (2022)
Francisco J Sánchez-Rivera, Bianca J Diaz, Edward R Kastenhuber, Henri Schmidt, Alyna Katti, Margaret C Kennedy, Vincent Tem, Yu-Jui Ho, Josef Leibold, Stella V Paffenholz, Francisco M Barriga, Kevan Chu, Sukanya Goswami, Alexandra N Wuest, Janelle M Simon, Kaloyan M Tsanov, Debyani Chakravarty, Hongxin Zhang, Christina S Leslie, Scott W Lowe, Lukas E Dow
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nature biotechnology 40 (6) (2022)
Emily R Kansler, Saïda Dadi, Chirag Krishna, Briana G Nixon, Efstathios Gregorios Stamatiades, Ming Liu, Fengshen Kuo, Jing Zhang, Xian Zhang, Kristelle Capistrano, Kyle A Blum, Kate Weiss, Ross M Kedl, Guangwei Cui, Koichi Ikuta, Timothy A Chan, Christina S Leslie, Abraham Ari Hakimi, Ming O Li
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies. Nature immunology 23 (6) (2022)
Erik Ladewig, Flavia Michelini, Komal Jhaveri, Hatice Ulku Osmanbeyoglu, Javier Carmona, Lauren Fairchild, Adler G Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christina S Leslie, Maurizio Scaltriti, Eneda Toska
The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation. Cancer research 82 (12) (2022)
Blossom Akagbosu, Zakieh Tayyebi, Gayathri Shibu, Yoselin A Paucar Iza, Deeksha Deep, Yollanda Franco Parisotto, Logan Fisher, H Amalia Pasolli, Valentin Thevin, Rasa Elmentaite, Maximilian Martin Ludwig Knott, Saskia Hemmers, Lorenz Jahn, Christin Friedrich, Jacob G Verter, Zhong-Min Wang, Marcel R M van den Brink, Georg Gasteiger, Thomas G P Grünewald, Julien C Marie, Christina S Leslie, Alexander Y Rudensky, Chrysothemis C Brown
Novel antigen-presenting cell imparts T reg -dependent tolerance to gut microbiota. Nature 610 (7933) (2022)
Meghana Kshirsagar, Han Yuan, Juan Lavista Ferres, Christina S Leslie
BindVAE: Dirichlet variational autoencoders for de novo motif discovery from accessible chromatin. Genome biology 23 (1) (2022)
Chun Chou, Xian Zhang, Chirag Krishna, Briana G Nixon, Saida Dadi, Kristelle J Capistrano, Emily R Kansler, Miranda Steele, Jian Han, Amy Shyu, Jing Zhang, Efstathios Gregorios Stamatiades, Ming Liu, Shun Li, Mytrang H Do, Chaucie Edwards, Davina S Kang, Chin-Tung Chen, Iris H Wei, Emmanouil P Pappou, Martin R Weiser, Julio Garcia-Aguilar, J Joshua Smith, Christina S Leslie, Ming O Li
Programme of self-reactive innate-like T cell-mediated cancer immunity. Nature 605 (7908) (2022)
S Dhara, Sagar Chhangawala, H Chintalapudi, G Askan, V Aveson, Alexandra Massa, L Zhang, D Torres, Alvin P Makohon-Moore, N Lecomte, J P Melchor, J Bermeo, A Cardenas, S Sinha, Danielle Glassman, Remy Nicolle, Richard A Moffitt, K H Yu, S Leppanen, S Laderman, B Curry, J Gui, Vinod P Balachandran, Christine A Iacobuzio-Donahue, R Chandwani, Christina S Leslie, S D Leach
Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility. Nature communications 12 (1) (2021)
Olivier Elemento, Christina S Leslie, Johan Lundin, Georgia Tourassi
Artificial intelligence in cancer research, diagnosis and therapy. Nature reviews. Cancer 21 (12) (2021)
Merve Sahin, Wilfred Wong, Yingqian Ada Zhan, Kinsey Van Deynze, Richard P Koche, Christina S Leslie
HiC-DC+ enables systematic 3D interaction calls and differential analysis for Hi-C and HiChIP. Nature communications 12 (1) (2021)
Yi Zhong, Sarah K Walker, Yuri Pritykin, Christina S Leslie, Alexander Y Rudensky, Joris van der Veeken
Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families. Nature immunology 23 (1) (2021)
Guotai Xu, Sagar Chhangawala, Emiliano Cocco, Pedram Razavi, Yanyan Cai, Jordan E Otto, Lorenzo Ferrando, Pier Selenica, Erik Ladewig, Carmen Chan, Arnaud Da Cruz Paula, Matthew Witkin, Yuanming Cheng, Jane Park, Cristian Serna-Tamayo, HuiYong Zhao, Fan Wu, Mirna Sallaku, Xuan Qu, Alison Zhao, Clayton K Collings, Andrew R D'Avino, Komal Jhaveri, Richard P Koche, Ross L Levine, Jorge Sergio Reis-Filho, Cigall Kadoch, Maurizio Scaltriti, Christina S Leslie, Jose Baselga, Eneda Toska
ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nature genetics 52 (2) (2020)
Diu T T Nguyen, Yuheng Lu, Karen L Chu, Xuejing Yang, Sun-Mi Park, Zi-Ning Choo, Christopher R Chin, Camila Prieto, Alexandra Schurer, Ersilia Barin, Angela M Savino, Saroj Gourkanti, Payal Patel, Ly P Vu, Christina S Leslie, Michael Gregory Kharas
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells. Nature communications 11 (1) (2020)
Gerard Minuesa, Steven K Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z Rotsides, James Taggart, Andrea Rizzi, Levi N Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C Passarelli, Lauren Fairchild, Carolina Adura, J Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K Eibl, Gregory M Ross, Shibani Bhattacharya, Derek S Tan, Christina S Leslie, Thijs Beuming, Dinshaw J Patel, Yehuda Goldgur, John D Chodera, Michael Gregory Kharas
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nature communications 10 (1) (2019)
Han Yuan, Meghana Kshirsagar, Lee Zamparo, Yuheng Lu, Christina S Leslie
BindSpace decodes transcription factor binding signals by large-scale sequence embedding. Nature methods 16 (9) (2019)
Catherine Konopacki, Yuri Pritykin, Yury P Rubtsov, Christina S Leslie, Alexander Y Rudensky
Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nature immunology 20 (2) (2019)
Orr-El Weizman, Eric Song, Nicholas M Adams, Andrew D Hildreth, Luke Riggan, Chirag Krishna, Oscar A Aguilar, Christina S Leslie, James R Carlyle, Joseph C Sun, Timothy E O'Sullivan
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nature immunology 20 (8) (2019)
Hatice Ulku Osmanbeyoglu, Fumiko Shimizu, Angela Rynne-Vidal, Direna Alonso-Curbelo, Hsuan-An Chen, Hannah Y Wen, Tsz-Lun Yeung, Petar Jelinic, Pedram Razavi, Scott W Lowe, Samuel C Mok, Gabriela Chiosis, Douglas A Levine, Christina S Leslie
Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers. Nature communications 10 (1) (2019)
Jing-Ping Hsin, Yuheng Lu, Gabriel B Loeb, Christina S Leslie, Alexander Y Rudensky
The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types. Nature immunology 19 (10) (2018)
Eneda Toska, Hatice U Osmanbeyoglu, Hatice Ulku Osmanbeyoglu, Carmen Chan, Ronald C Hendrickson, Moshe Elkabets, Maura N Dickler, Maurizio Scaltriti, Christina S Leslie, Scott A Armstrong, Jose Baselga
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science (New York, N.Y.) 355 (6331) (2017)

Christina S Leslie.css-eqlu8i{font-size:small;padding-left:4px;} (Christina Leslie, C S Leslie)

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Christina S Leslie (Christina Leslie, C S Leslie)