Epidemiologic Trends of Thalassemia, 2006-2018: A Nationwide Population-Based Study.
Jee-Soo LeeTae-Min RheeKibum JeonYonggeun ChoSeung-Woo LeeKyung-Do HanMoon-Woo SeongSung-Sup ParkYoung Kyung LeePublished in: Journal of clinical medicine (2022)
Thalassemia is the most common form of hereditary anemia. Here, we aimed to investigate the 13-year trend of the epidemiologic profiles and risk of comorbidities in thalassemia using a nationwide population-based registry in Korea. Diagnosis of thalassemia, the comorbidities and transfusion events in patients with thalassemia were identified in the Korean National Health Insurance database, which includes the entire population. The prevalence of thalassemia increased from 0.74/100,000 in 2006 to 2.76/100,000 in 2018. Notably, the incidence rate has nearly doubled in the last 2 years from 0.22/100,000 in 2016 to 0.41/100,000 in 2018. The annual transfusion rate gradually decreased from 34.7% in 2006 to 20.6% in 2018. Transfusion events in patients with thalassemia were significantly associated with the risk of comorbidities (diabetes: odds ratio [OR] = 3.68, 95% confidence interval [CI] = 2.59-5.22; hypertension: OR = 3.06, 95% CI = 2.35-4.00; dyslipidemia: OR = 1.72, 95% CI = 1.22-2.43; atrial fibrillation: OR = 3.52, 95% CI = 1.69-7.32; myocardial infarction: OR = 3.02, 95% CI = 1.09-8.38; stroke: OR = 3.32, 95% CI = 2.05-5.36; congestive heart failure: OR = 2.83, 95% CI = 1.62-4.97; end-stage renal disease: OR = 3.25, 95% CI = 1.96-5.37). Early detection of comorbidities and timely intervention are required for the management of thalassemia.
Keyphrases
- sickle cell disease
- heart failure
- atrial fibrillation
- health insurance
- chronic kidney disease
- end stage renal disease
- randomized controlled trial
- cardiovascular disease
- left ventricular
- risk factors
- peritoneal dialysis
- blood pressure
- healthcare
- skeletal muscle
- adipose tissue
- brain injury
- oral anticoagulants
- cross sectional
- affordable care act
- mitral valve
- direct oral anticoagulants