Validating Techniques for Measurement of Cutaneous Neurofibromas: Recommendations for Clinical Trials.

Raquel D ThalheimerVanessa L MerkerK Ina LyAmanda ChamplainJennifer SawayaNaomi L AskenaziHamilton P HerrJennifer L W DaJustin T JordanAlona MuzikanskyElizabeth Morehouse PearceFernanda H SakamotoJaishri O BlakeleyR Rox AndersonScott R Plotkinnull null

Published in: Neurology (2021)

HFUS and 3D photography demonstrate excellent reliability whereas digital calipers have good to excellent reliability in measuring cNF. The MDD for each technique was used to create tables of proposed thresholds for investigators to use as guides for clinical trials focused on cNF size. These criteria should be updated as the performance of these end points is evaluated.

Keyphrases

clinical trial
phase ii
major depressive disorder
open label
study protocol
double blind
clinical practice
phase iii
randomized controlled trial