Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans.

Li CheWenna ChiYu QiaoJie ZhangXinhua SongYe LiuLei LiJiaoyuan JiaMaria G PiloJingxiao WangAntonio CiglianoZhilong MaWenhua KuangZefang TangZemin ZhangGuanghou ShuiSilvia RibbackFrank DombrowskiMatthias EvertRosa Maria PascaleCarla CossuGiovanni Mario PesTimothy F OsborneDiego F CalvisiXin ChenLigong Chen

Published in: Gut (2019)

Our study uncovers a novel functional crosstalk between aberrant lipogenesis and cholesterol biosynthesis pathways in hepatocarcinogenesis, whose concomitant inhibition might represent a therapeutic option for HCC.

Keyphrases

fatty acid
low density lipoprotein
high fat diet induced
cell wall
type diabetes
insulin resistance
metabolic syndrome
skeletal muscle
wild type