Prospective memory performance in veterans with and without histories of mild traumatic brain injury: effect of the apolipoprotein E (APOE) ε4 genotype.
Jennifer S AdlerErin D OzturkVictoria C MerrittLisa Delano-WoodDawn M SchiehserMark W BondiMonica T LyAdan Ton-LoyScott F SorgPublished in: Journal of clinical and experimental neuropsychology (2024)
mTBI history and APOE-ε4 genotype status were independently associated with worse PM performance compared to those without head injury histories or possession of the APOE-e4 genotype. Performance on the MIST 15-min delay was worse in Veterans with both risk factors (mTBI history and APOE-ε4 positivity). Findings suggest that genetic status may modify outcomes even in relatively young Veterans with mTBI histories. Future research examining longitudinal associations and links to neuroimaging and biomarker data are needed.
Keyphrases
- mild traumatic brain injury
- cognitive decline
- high fat diet
- risk factors
- mild cognitive impairment
- particulate matter
- adipose tissue
- air pollution
- working memory
- current status
- type diabetes
- heavy metals
- cross sectional
- metabolic syndrome
- middle aged
- polycyclic aromatic hydrocarbons
- optic nerve
- skeletal muscle
- weight loss
- deep learning
- water soluble