Neoantigen load and HLA-class I expression identify a subgroup of tumors with a T-cell-inflamed phenotype and favorable prognosis in homologous recombination-proficient high-grade serous ovarian carcinoma.

Hirokazu MatsushitaKosei HasegawaKatsutoshi OdaShogo YamamotoKayo AsadaTakahiro KarasakiAkira YabunoAkira NishijimaTakahide NejoYukari KobayashiSho SatoYuji IkedaManami MiyaiYusuke TakahashiRui YamaguchiKeiichi FujiwaraHiroyuki AburataniKazuhiro Kakimi

Published in: Journal for immunotherapy of cancer (2021)

Our results suggest that immune checkpoint inhibitors might be an alternative to explore in HR-proficient cases which currently do not benefit from PARP inhibition.

Keyphrases

high grade
dna repair
dna damage
low grade
poor prognosis
binding protein
randomized controlled trial
phase iii
study protocol