Heterogeneity and reciprocity of FVIII and VWF expression, and the response to shear stress in cultured human endothelial cells.

Christine Hough Colleen Notley Aomei Mo Barbara Videl David Lillicrap

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Variable levels of FVIII and VWF RNA and protein exist in a subset of cultured human endothelial cells. Higher levels of FVIII present in hLECs co-localize with VWF and are released together when exposed to a secretagogue.

Keyphrases

endothelial cells
high glucose
vascular endothelial growth factor
poor prognosis
binding protein
single cell
amino acid
pluripotent stem cells