Fermentation of Panax notoginseng root extract polysaccharides attenuates oxidative stress and promotes type I procollagen synthesis in human dermal fibroblast cells.
Shiquan YouXiuqin ShiDan YuDan ZhaoQuan AnDongdong WangJiachan ZhangMeng LiChangtao WangPublished in: BMC complementary medicine and therapies (2021)
It was shown that FPNP could inhibit the damage of collagen and elastin induced by H2O2 by activating the TGF-β/Smad signaling pathway, thereby protecting against the oxidative damage induced by hydrogen peroxide. FPNP may be an effective attenuating healing agent that protects the skin from oxidative stress and wrinkles.
Keyphrases
- oxidative stress
- induced apoptosis
- hydrogen peroxide
- signaling pathway
- wound healing
- transforming growth factor
- epithelial mesenchymal transition
- nitric oxide
- endothelial cells
- diabetic rats
- ischemia reperfusion injury
- pi k akt
- dna damage
- endoplasmic reticulum stress
- cell cycle arrest
- induced pluripotent stem cells
- pluripotent stem cells
- soft tissue
- type iii
- cell proliferation
- lactic acid
- heat shock