High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.
Alexander C BashoreHanying YanChenyi XueLucie Y ZhuEunyoung KimThomas MawsonJohana CoronelAllen ChungNadja SachsSebastian HoLeila S RossMichael KissnerEmmanuelle PassegueRobert C BauerLars MaegdefesselMingyao LiMuredach P ReillyPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. These findings facilitate both the mapping of cardiovascular disease susceptibility loci to specific cell types and the identification of novel molecular and cellular therapeutic targets for the treatment of the disease.
Keyphrases
- single cell
- cardiovascular disease
- rna seq
- endothelial cells
- high throughput
- induced pluripotent stem cells
- cell therapy
- pluripotent stem cells
- pain management
- type diabetes
- genome wide
- cardiovascular risk factors
- gene expression
- coronary artery disease
- cardiovascular events
- mesenchymal stem cells
- metabolic syndrome
- chronic pain
- high density
- bone marrow