The safety and efficacy of total mesorectal excision (TME) surgery following dose-escalation: Surgical outcomes from the organ preservation in early rectal adenocarcinoma (OPERA) trial, a European multicentre phase 3 randomised trial (NCT02505750).
Arthur Sun MyintChristopher RaoNicolas BarbetBrice ThamphyaTanguy Pace-LoscosRenaud SchiappaNicolas MagnéIsabelle Martel-LafayLaurent MineurMelanie DeberneThomas ZilliAmandeep DhaddaJean Pierre GerardPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2023)
Dose escalation can facilitate nonsurgical treatment for cT2-3 rectal cancer patients who are fit but wish to avoid TME surgery and stoma. If TME surgery is required, then it can be performed safely and effectively.
Keyphrases
- minimally invasive
- coronary artery bypass
- rectal cancer
- study protocol
- open label
- surgical site infection
- clinical trial
- squamous cell carcinoma
- randomized controlled trial
- locally advanced
- radiation therapy
- phase iii
- percutaneous coronary intervention
- acute coronary syndrome
- cross sectional
- dual energy
- positron emission tomography
- combination therapy