Radiation Therapy With or Without Cisplatin for Local Recurrences of Endometrial Cancer: Results From an NRG Oncology/GOG Prospective Randomized Multicenter Clinical Trial.
Ann H KloppDanielle EnserroMatthew A PowellMarcus RandallJulian C SchinkRobert S MannelLaura HolmanDavid BenderChristina L KushnirFloor J BackesSusan L ZweizigSteven WaggonerKristin A BradleyLana DeSouza LawrenceParviz HanjaniChristopher J DarusWilliam SmallHiginia R CardenesJonathan M FeddockDavid Scott MillerPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Excellent outcomes can be achieved for women with localized recurrences of endometrial cancer when treated with radiation therapy. The addition of chemotherapy does not improve PFS for patients treated with definitive radiation therapy for recurrent endometrial cancer and increases acute toxicity. Patients with low-grade and vaginal recurrences who constituted the majority of those enrolled are best treated with radiation therapy alone.
Keyphrases
- endometrial cancer
- radiation therapy
- low grade
- locally advanced
- double blind
- clinical trial
- high grade
- radiation induced
- open label
- phase ii
- phase iii
- placebo controlled
- liver failure
- palliative care
- rectal cancer
- squamous cell carcinoma
- oxidative stress
- randomized controlled trial
- study protocol
- drug induced
- cross sectional
- adipose tissue
- chemotherapy induced