SLC2A3 promotes tumor progression through lactic acid-promoted TGF-β signaling pathway in oral squamous cell carcinoma.

Wei JiangSheng XuPing Li

Published in: PloS one (2024)

Our study reveals that SLC2A3 expression was up-regulated in OSCC. SLC2A3 activates the TGF-β signaling pathway through lactic acid generated from glycolysis, thus regulating the biological behavior of OSCC.

Keyphrases

lactic acid
signaling pathway
poor prognosis
transforming growth factor
pi k akt
epithelial mesenchymal transition
induced apoptosis
long non coding rna