Retrospective, Landmark Analysis of Long-term Adult Morbidity Following Allogeneic HSCT for Inborn Errors of Immunity in Infancy and Childhood.
James W DayReem ElfekyBethany NicholsonRupert GoodmanRachel PearceThomas A FoxAusten WorthClaire BoothPaul VeysBen CarpenterRachael HoughH Bobby GasparPenny TitmanDeborah RidoutSarita WorkmanFernando HernandesKit SandfordArian LaurenceMari CampbellSiobhan O BurnsEmma Catherine MorrisPublished in: Journal of clinical immunology (2022)
Although most patients achieved excellent, durable immune reconstitution with infrequent transplant-related complications, very late complications are common and associated with mixed chimerism post-HSCT. Early intervention to correct mixed chimerism may improve long-term outcomes and adult health following HSCT for IEI in childhood.
Keyphrases
- hematopoietic stem cell
- childhood cancer
- end stage renal disease
- chronic kidney disease
- ejection fraction
- healthcare
- newly diagnosed
- randomized controlled trial
- public health
- stem cell transplantation
- allogeneic hematopoietic stem cell transplantation
- bone marrow
- risk factors
- prognostic factors
- mental health
- early life
- peritoneal dialysis
- emergency department
- low dose
- young adults
- cross sectional
- patient safety
- weight gain
- high dose
- social media
- body mass index
- risk assessment
- patient reported outcomes
- acute myeloid leukemia