Follicular Fluid and Blood Monitorization of Infertility Biomarkers in Women with Endometriosis.
Ana Teresa BrincaAna María PeiróPilar Matallín EvangelioIrene ElenoAntonio Helio OlianiVladimiro SilvaLuís F VicenteAna Cristina RamalhinhoEugenia GallardoPublished in: International journal of molecular sciences (2024)
Infertility is recognized globally as a social disease and a growing medical condition, posing a significant challenge to modern reproductive health. Endometriosis, the third-most frequent gynecologic disorder, is one of the most common and intricate conditions that can lead to female infertility. Despite extensive research, the etiology, malignant transformation, and biological therapy of endometriosis remain unknown. Blood and follicular fluid are two matrices that have been carefully studied and can provide insights into women's health. These matrices are clinically significant because they contain metabolites closely associated with women's illness stage and reproductive outcomes. Nowadays, the application of metabolomic analysis in biological matrices may be able to predict the outcome of assisted reproductive technologies with greater precision. From a molecular viewpoint on reproductive health, we evaluate and compare the utilization of human follicular fluid and blood as matrices in analysis for diagnostic and assisted reproductive technology (ART) predictors of success for endometriosis patients. In the follicular fluid (FF), plasma, and serum of endometriosis-affected women, researchers identified dysregulations of oxidative stress, upregulation of several immune factors, and aberrations in energy metabolic pathways. The altered signatures negatively correlate with the overall oocyte and embryo quality and fertilization rate.
Keyphrases
- polycystic ovary syndrome
- healthcare
- pregnancy outcomes
- oxidative stress
- insulin resistance
- end stage renal disease
- newly diagnosed
- public health
- endothelial cells
- chronic kidney disease
- dna damage
- cervical cancer screening
- adipose tissue
- stem cells
- cell proliferation
- pregnant women
- ms ms
- type diabetes
- poor prognosis
- endometrial cancer
- endoplasmic reticulum stress
- long non coding rna
- patient reported outcomes
- heat shock protein
- bone marrow
- pluripotent stem cells
- data analysis
- replacement therapy