Extracellular Vesicles from hiPSC-derived NSCs Protect Human Neurons against Aβ-42 Oligomers Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation.
Shama RaoLeelavathi N MadhuRoshni Sara BabuAdvaidhaa NagarajanRaghavendra UpadhyaEsha NarvekarAshok K ShettyPublished in: bioRxiv : the preprint server for biology (2024)
The findings demonstrate that an optimal dose of hiPSC-NSC-EVs could significantly decrease the degeneration of human neurons induced by Aβ-42o. The results also support further research into the effectiveness of hiPSC-NSC-EVs in AD, particularly their proficiency in preserving neurons and slowing disease progression.