The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro.
Thit Mynster KronborgJuliana Frohnert HansenÅse Krogh RasmussenKatrin VorkampClaus Henrik NielsenMarie FrederiksenJacob Hofman-BangChristoffer Holst HahnLouise RamhøjUlla Feldt-RasmussenPublished in: PloS one (2017)
DE-71 inhibited differentiated thyroid cell functions in a two phase response manner and a concentration-dependent inhibition of Tg and cAMP production, respectively, as well as expression of mRNA encoding Tg, TPO and TSHr. Our findings suggest an inhibiting effect of PBDEs on thyroid cells.
Keyphrases
- binding protein
- induced apoptosis
- endothelial cells
- poor prognosis
- signaling pathway
- cell cycle arrest
- single cell
- cell therapy
- induced pluripotent stem cells
- pluripotent stem cells
- endoplasmic reticulum stress
- cell death
- stem cells
- oxidative stress
- mesenchymal stem cells
- gas chromatography
- high resolution
- simultaneous determination