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IgA antibody immunotherapy targeting GD2 is effective in preclinical neuroblastoma models.

Marjolein C StipMitchell EversMaaike NederendChilam ChanKarli R ReidingMirjam J DamenAlbert J R HeckSofia KoustoulidouRuud RamakersGerard C KrijgerRemmert de RoosEdouard SouteyrandAnnelisa M CornelMiranda P DierselhuisMarco JansenMark de BoerThomas ValeriusGeert van TeteringJeanette H W LeusenFriederike Meyer-Wentrup
Published in: Journal for immunotherapy of cancer (2023)
IgA3.0 ch14.18 is a promising new therapy for neuroblastoma, showing (1) increased half-life compared to natural IgA antibodies, (2) increased protein stability enabling effortless production and purification, (3) potent CD89-mediated tumor killing in vitro by healthy subjects and patients with neuroblastoma and (4) antitumor efficacy in long-term mouse neuroblastoma models.
Keyphrases
  • stem cells
  • cancer therapy
  • mesenchymal stem cells
  • drug delivery