Sirolimus treatment for paediatric head and neck lymphatic malformations: a systematic review.
Alberto Maria SaibeneCecilia RossoGiovanni FelisatiLorenzo PignataroAntonio SchindlerGiorgio GhilardiGiacomo CollettiMichele GaffuriFrancesco MozzanicaPublished in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2023)
Despite promising results for sirolimus treatment in lymphatic malformation, the efficacy and safety profile of remains unclear due to the lack of high-quality studies. Systematic reporting of known side effects, especially in younger children, should assist clinicians in minimising treatment-associated risks. At the same time, we advocate for prospective multicentre studies with minimum reporting standards to facilitate improved candidate selection.