High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats.
Xiyuan ZhangGuanying Bianca XuDan ZhouYuan-Xiang PanPublished in: Genes & nutrition (2018)
Our study demonstrated that HF diet regulated cellular senescence marker p16(INK4a) through chromatin modifications, which may promote hepatic fat accumulation and steatosis.
Keyphrases
- high fat diet
- dna damage
- adipose tissue
- insulin resistance
- transcription factor
- genome wide
- gene expression
- endothelial cells
- poor prognosis
- stress induced
- copy number
- oxidative stress
- weight loss
- type diabetes
- skeletal muscle
- genome wide identification
- fatty acid
- long non coding rna
- binding protein
- high fat diet induced