Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes.
Wenwen WangJiahuan LiuBinzhou YangZhongshuang MaGuiping LiuWeigan ShenYu ZhangPublished in: PloS one (2017)
Platelet-derived microparticles (PMPs) are closely associated with disease activity in rheumatoid arthritis (RA) and contribute to the inflammatory process. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play important roles in the progression of joint destruction. The aim of this study is to demonstrate whether PMPs affect the adhesion and motility of RA-FLSs. Our data indicated that PMPs promoted migration, invasion and adhesion to extracellular matrix (ECM) of RA-FLSs. Further study showed that PMPs up-regulated the expression of matrix metalloproteinase-1 (MMP1) and increased the level of phosphorylation of NF-κB (p-NF-κB) and Erk (p-Erk) in RA-FLSs. These results suggest that PMPs promote RA-FLSs adhesion and motility presumably by increasing MMP1 via activating Erk-mediated NF-κB pathway.
Keyphrases
- deep learning
- rheumatoid arthritis
- disease activity
- signaling pathway
- biofilm formation
- pi k akt
- systemic lupus erythematosus
- ankylosing spondylitis
- extracellular matrix
- rheumatoid arthritis patients
- cell migration
- interstitial lung disease
- juvenile idiopathic arthritis
- oxidative stress
- lps induced
- cell proliferation
- endothelial cells
- pseudomonas aeruginosa
- nuclear factor
- poor prognosis
- toll like receptor
- transcription factor
- immune response
- electronic health record
- data analysis
- cell adhesion
- wound healing