[Unmet needs in the therapy of type 2 diabetes mellitus. How can barriers to insulin therapy be overcome?]

According to the current treatment guidelines, the therapy of type 2 diabetes mellitus should follow a stepwise therapy adjustment and intensification approach as soon as blood glucose control is no longer achieved with preceding diabetes treatment. However, clinical practice shows that the recommended steps for therapy escalation are often not followed, and treatment intensification is delayed. Especially the initiation with insulin and its intensification is often considerably delayed, even though the patient has high blood glucose levels, remaining above target even for years. In addition, treatment adherence is often lower with insulin therapy than with other antidiabetic treatment. This is problematic in terms of the risks for morbidity and mortality due to microvascular and macrovascular complications. The phenomenon known as therapeutic inertia occurs mainly with chronic diseases. The reasons thereof are complex and can be related to the person with diabetes and/or the healthcare professional. Main reasons are the frequency of insulin injections and a rigid treatment regimen, which are perceived as inconvenient and restrictive. Also, the complexity of insulin treatment, the required training, and its negative image of insulin as "last option" are negatively perceived. Results from surveys show that patients and physicians would prefer injections to be administered less frequently. Experience with once-weekly glucagon-like peptide-1 receptor agonists (GLP-1-RA) has been encouraging in terms of efficacy, adherence, and patient satisfaction. Intensive research is currently being conducted on novel insulin analogues with once-weekly application.