Associations of Dynapenic Obesity and Sarcopenic Obesity with the Risk of Complications in COVID-19.
Laura Pérez Campos MayoralCarlos Alberto Matias-CervantesEduardo Pérez-Campos MayoralCarlos Romero DíazLuis Ángel Laguna BarriosMaría Del Socorro Pina CansecoMargarito Martínez CruzEduardo Pérez-Campos MayoralCarlos Josué Solórzano MataFrancisco Javier Rodal CanalesHéctor Martínez RuízMaría Teresa Hernández HuertaPublished in: International journal of molecular sciences (2022)
Ageing is associated with changes in body composition, such as low muscle mass (sarcopenia), decreased grip strength or physical function (dynapenia), and accumulation of fat mass. When the accumulation of fat mass synergistically accompanies low muscle mass or reduced grip strength, it results in sarcopenic obesity and dynapenic obesity, respectively. These types of obesity contribute to the increased risk of cardiovascular disease and mortality in the elderly, which could increase the damage caused by COVID-19. In this review, we associated factors that could generate a higher risk of COVID-19 complications in dynapenic obesity and sarcopenic obesity. For example, skeletal muscle regulates the expression of inflammatory cytokines and supports metabolic stress in pulmonary disease; hence, the presence of dynapenic obesity or sarcopenic obesity could be related to a poor prognosis in COVID-19 patients.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- type diabetes
- poor prognosis
- high fat diet induced
- weight gain
- skeletal muscle
- body composition
- sars cov
- cardiovascular disease
- coronavirus disease
- adipose tissue
- long non coding rna
- coronary artery disease
- body mass index
- oxidative stress
- risk factors
- postmenopausal women
- bone mineral density
- fatty acid
- high intensity