Type 1 interferon status in systemic lupus erythematosus: a longitudinal analysis.
Melissa NorthcottSarah JonesRachel KoelmeyerJulie BoninFabien B VincentRangi Kandane-RathnayakeAlberta Y HoiEric F MorandPublished in: Lupus science & medicine (2022)
Although IFN high status is associated with indicators of more severe SLE, in the majority of patients, ISGs are stable across time and do not correlate with disease activity. Changes in ISG expression may be seen with high-dose, but not routine dose, glucocorticoid exposure. These findings suggest baseline but not serial ISG measurement may be of value in the management of SLE.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- high dose
- end stage renal disease
- ankylosing spondylitis
- juvenile idiopathic arthritis
- dendritic cells
- ejection fraction
- chronic kidney disease
- poor prognosis
- newly diagnosed
- peritoneal dialysis
- low dose
- prognostic factors
- immune response
- early onset
- binding protein
- long non coding rna
- patient reported