Amyloidosis, inflammation, and oxidative stress in the heart of an alkaptonuric patient.
Lia MillucciLorenzo GhezziEugenio PaccagniniGiovanna GiorgettiCecilia VitiDaniela BraconiMarcella LaschiMichela GeminianiPatrizia SoldaniPietro LupettiMaurizio OrlandiniChiara BenvenutiFederico PerfettoAdriano SpreaficoGiulia BernardiniAnnalisa SantucciPublished in: Mediators of inflammation (2014)
SAA-amyloidosis was present in the aortic valve from an AKU patient and colocalized with ochronotic pigment as well as with tissue calcification, lipid oxidation, macrophages infiltration, cell death, and tissue degeneration. A local HGD expression in human cardiac tissue has also been ascertained suggesting a consequent local production of ochronotic pigment in AKU heart.
Keyphrases
- aortic valve
- oxidative stress
- cell death
- heart failure
- transcatheter aortic valve replacement
- case report
- endothelial cells
- transcatheter aortic valve implantation
- aortic valve replacement
- poor prognosis
- atrial fibrillation
- chronic kidney disease
- multiple myeloma
- dna damage
- ischemia reperfusion injury
- fatty acid
- cell proliferation
- binding protein
- long non coding rna