Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer.
Marta TrübFranziska UhlenbrockChristina ClausPetra HerzigMartin ThelenVaios KaranikasMarina BacacMaria AmannRosemarie AlbrechtClaudia Ferrara-KollerDaniela ThommenSacha RothschieldSpasenija Savic PrinceKirsten D MertzGieri CathomasRobert RosenbergViola Heinzelmann-SchwarzMark WieseDidier LardinoisPablo UmanaChristian KleinHeinz LaubliAbhishek S KashyapAlfred ZippeliusPublished in: Journal for immunotherapy of cancer (2021)
Our study provides mechanistic insights into T cell stimulation induced by FAP-4-1BBL in primary human tumors and supports the investigation of FAP-4-1BBL compound in early clinical trials.