Feasibility of Brain Atrophy Measurement in Clinical Routine without Prior Standardization of the MRI Protocol: Results from MS-MRIUS, a Longitudinal Observational, Multicenter Real-World Outcome Study in Patients with Relapsing-Remitting MS.
Robert ZivadinovNiels P BergslandJ R KornMichael G DwyerNasreen KhanJennie MedinJ C PriceBianca Weinstock-GuttmanD Silvanull nullPublished in: AJNR. American journal of neuroradiology (2017)
Brain atrophy was more readily assessed by estimating the percentage lateral ventricle volume change on T2-FLAIR compared with the percentage brain volume change or percentage lateral ventricle volume change using 2D- or 3D-T1WI in this observational retrospective study. Although measurement of the percentage brain volume change on 3D-T1WI remains the criterion standard and should be encouraged in future prospective studies, T2-FLAIR-derived percentage lateral ventricle volume change may be a more feasible surrogate when historical or other practical constraints limit the availability of percentage brain volume change on 3D-T1WI.
Keyphrases
- multiple sclerosis
- white matter
- resting state
- functional connectivity
- randomized controlled trial
- pulmonary hypertension
- mitral valve
- mass spectrometry
- pulmonary artery
- minimally invasive
- cerebral ischemia
- cross sectional
- heart failure
- magnetic resonance
- computed tomography
- clinical practice
- disease activity
- subarachnoid hemorrhage