A community-based lung cancer rapid tissue donation protocol provides high-quality drug-resistant specimens for proteogenomic analyses.
Theresa A BoyleGwendolyn P QuinnMatthew B SchabathTeresita Muñoz-AntoniaJames J SallerLuisa F DuarteLaura S HairJamie K TeerDerek Y ChiangRebecca LearyConnie C WongAlexander SavchenkoAngad P SinghLaSalette CharetteKate MendellGullu GorgunScott J AntoniaAlberto A ChiapporiBenjamin C CreelanJhanelle E GrayEric B HauraPublished in: Cancer medicine (2019)
Post-therapy specimens demonstrated PD-L1 heterogeneity and an acyl glycerol kinase to B-rapidly accelerated fibrosarcoma (AGK-BRAF) fusion in a patient with an EML4-ALK-positive lung adenocarcinoma as a potential resistance mechanism to ALK inhibitor therapy. Rapid tissue donation collection of postmortem tissue from lung cancer patients is a novel approach to cancer research that enables studies of molecular evolution and drug resistance.
Keyphrases
- drug resistant
- multidrug resistant
- acinetobacter baumannii
- advanced non small cell lung cancer
- randomized controlled trial
- single cell
- stem cells
- case report
- loop mediated isothermal amplification
- bone marrow
- risk assessment
- pseudomonas aeruginosa
- single molecule
- tyrosine kinase
- protein kinase
- young adults
- fatty acid
- human health
- replacement therapy
- wild type
- sensitive detection