IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma.

Megan MontoyaSara A CollinsPavlina ChuntovaTrishna S PatelTakahide NejoAkane YamamichiNoriyuki Kasahara Hideho Okada

Published in: Neuro-oncology (2024)

Our results indicate that reprogramming of glioma-infiltrating myeloid cells by in vivo expression of IRF8 may reduce immunosuppression and enhance antigen presentation, achieving improved tumor control.

Keyphrases

dendritic cells
induced apoptosis
poor prognosis
cell cycle arrest
stem cells
bone marrow
acute myeloid leukemia
endoplasmic reticulum stress
case report
immune response
pi k akt