Upconverting Oil-Laden Hollow Mesoporous Silica Microcapsules for Anti-Stokes-Based Biophotonic Applications.
Hak-Lae LeeJung Hwan ParkHyun-Seok ChoeMyung-Soo LeeJeong-Min ParkNaoyuki HaradaYoichi SasakiNobuhiro YanaiNobuo KimizukaJintao ZhuSuk Ho BhangJae-Hyuk KimPublished in: ACS applied materials & interfaces (2019)
A recyclable, aqueous phase functioning and biocompatible photon upconverting system is developed. Hollow mesoporous silica microcapsules (HMSMs) with ordered radial mesochannels were employed, for the first time, as vehicles for the post-encapsulation of oil phase triplet-triplet annihilation upconversion (TTA-UC), with the capability of homogeneous suspension in water. In-depth characterization of such upconverting oil-laden HMSMs (UC-HMSMs) showed that the mesoporous silica shells reversibly stabilized the encapsulated UC oil in water to allow efficient upconverted emission, even under aerated conditions. In addition, the UC-HMSMs were found to actively bind to the surface of human mesenchymal stem cells without significant cytotoxicity and displayed upconverted bright blue emission under 640 nm excitation, indicating a potential of our new TTA-UC system in biophotonic applications. These findings reveal the great promise of UC-HMSMs to serve as ideal vehicles not only for ultralow-power in vivo imaging but also for stem cell labeling, to facilitate the tracking of tumor cells in animal models.
Keyphrases
- stem cells
- mesenchymal stem cells
- energy transfer
- fatty acid
- photodynamic therapy
- endothelial cells
- high resolution
- gene expression
- bone marrow
- molecularly imprinted
- metal organic framework
- big data
- fluorescent probe
- risk assessment
- mass spectrometry
- cell therapy
- single cell
- ultrasound guided
- human health
- pluripotent stem cells