Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders.

Heath E O'BrienEilis HannonMatthew J HillCarolina C TosteMatthew J RobertsonJoanne E MorganGemma McLaughlinCathryn M LewisLeonard C SchalkwykLynsey S HallAntonio F PardiñasMichael J OwenMichael C O'DonovanJonathan MillNicholas J Bray

Published in: Genome biology (2018)

We have mapped eQTL operating in the human fetal brain, providing evidence that these confer risk to certain neuropsychiatric disorders, and identifying gene expression changes that potentially mediate susceptibility to these conditions.

Keyphrases

gene expression
genome wide
endothelial cells
poor prognosis
dna methylation
white matter
induced pluripotent stem cells
pluripotent stem cells
binding protein
long non coding rna
cerebral ischemia
brain injury
genome wide association
mass spectrometry
blood brain barrier