Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-linked data.
Paris J BaptisteAngel Yun WongAnna SchultzeCatherine M ClaseClemence LeyratElizabeth WilliamsonEmma Maud PowellJohannes F E MannMarianne CunningtonKoon TeoShrikant I BangdiwalaPeggy GaoKevin WingLaurie A TomlinsonPublished in: PLoS medicine (2024)
These results demonstrate variation in drug effects of ACEi and ARB for some outcomes by ethnicity and suggest the potential for adverse consequences from current UK guideline recommendations for ARB in preference to ACEi for Black individuals.