MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma.
Zhikui LiuYufeng WangChangwei DouLiankang SunQing LiLiang WangQiuran XuWei YangQingguang LiuKangsheng TuPublished in: Journal of experimental & clinical cancer research : CR (2018)
Taken together, this research supports the first evidence that miR-1468 plays an oncogenic role in HCC via activating PPAR-γ/AKT pathway by targeting CITED2 and UPF1, and represents a promising therapeutic strategy for HCC patients.
Keyphrases
- signaling pathway
- cell proliferation
- end stage renal disease
- ejection fraction
- newly diagnosed
- endothelial cells
- chronic kidney disease
- insulin resistance
- long non coding rna
- peritoneal dialysis
- prognostic factors
- type diabetes
- metabolic syndrome
- fatty acid
- patient reported outcomes
- long noncoding rna
- induced pluripotent stem cells
- pluripotent stem cells