CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing.
Francesco AielloGabriele Gallo AfflittoJi-Peng Olivia LiAlessio MartucciMassimo CesareoCarlo NucciPublished in: Journal of clinical medicine (2020)
The endocannabinoid system (ECS) is a complex regulatory system, highly conserved among vertebrates. It has been widely described in nearly all human tissues. In the conjunctiva and cornea, the ECS is believed to play a pivotal role in the modulation of the local inflammatory state as well as in the regulation of tissue repair and fibrosis, neo-angiogenesis and pain perception. This review aims to summarize all the available data on ECS expression and its function in ocular surface structures to provide a specific insight concerning its modulation in dry eye disease, and to propose directions for future research.
Keyphrases
- wound healing
- endothelial cells
- inflammatory response
- transcription factor
- vascular endothelial growth factor
- poor prognosis
- chronic pain
- pain management
- gene expression
- oxidative stress
- electronic health record
- current status
- pluripotent stem cells
- high resolution
- lps induced
- big data
- neuropathic pain
- diabetic retinopathy
- binding protein
- immune response
- data analysis
- artificial intelligence
- optical coherence tomography
- liver fibrosis