Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT).

Mohammad Bashashati Jakub FichnaF PiscitelliR CapassoA A IzzoA SibaevJ-P TimmermansN CenacN VergnolleV Di MarzoM Storr

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)

The effects of AA-5-HT on visceral sensation and colonic motility are differentially mediated by CB1, TRPV1 and non-CB1/TRPV1 mechanisms, possibly reflecting the distinct neuromodulatory roles of endocannabinoid and endovanilloid FAAH substrates in the mouse intestine.

Keyphrases

fatty acid
biofilm formation
insulin resistance
randomized controlled trial
neuropathic pain
ulcerative colitis
cancer therapy
cerebral ischemia
pseudomonas aeruginosa
escherichia coli
adipose tissue
metabolic syndrome
skeletal muscle
risk assessment
cystic fibrosis
candida albicans
brain injury