Establishment and characterization of an immortalized human chondrocyte cell line.

Jiashu YangYuting TangWensun ChenMing ZhangFangling HongDawei YangQianyi BaoYing YangYucui JinLingyun LiChangyan Ma

Published in: Biotechnology letters (2020)

Ectopic stable expression of TERT is an effective way to immortalized human chondrocyte. The immortalized chondrocytes displayed little cellular senescence, showed promise as an in vitro model to investigate osteoarthritis, and may be a promising resource for cell-based therapy for damaged cartilage.

Keyphrases

endothelial cells
induced pluripotent stem cells
poor prognosis
pluripotent stem cells
single cell
extracellular matrix
machine learning
big data
bone marrow
oxidative stress