HAR1: an insight into lncRNA genetic evolution.
Ella WatersPerla PucciMark HirstSimon ChapmanYuzhuo WangFrancesco CreaChristopher J HeathPublished in: Epigenomics (2021)
Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. HAR1 is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, HAR1A and HAR1B. Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study.
Keyphrases
- genome wide
- endothelial cells
- dna methylation
- long non coding rna
- genome wide identification
- genome wide association study
- genome wide analysis
- public health
- poor prognosis
- healthcare
- induced pluripotent stem cells
- copy number
- network analysis
- long noncoding rna
- pluripotent stem cells
- mental health
- high resolution
- transcription factor
- gene expression
- squamous cell
- genome wide association
- risk assessment
- subarachnoid hemorrhage
- social media
- health promotion
- climate change
- bioinformatics analysis
- amino acid
- human health