Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish.

Yi-Lin YanThomas DesvignesRuth BremillerCatherine WilsonDanielle M DillonSamantha HighBruce DraperCharles Loren BuckJohn H Postlethwait

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)

In zebrafish, gsdf regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra-ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS), suggesting a role for a related TGFB signaling molecule in the etiology of PCOS. Developmental Dynamics 246:925-945, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

type diabetes
metabolic syndrome
polycystic ovary syndrome
poor prognosis
weight loss
signaling pathway
gene expression
dna methylation
adipose tissue
transcription factor
long non coding rna
pluripotent stem cells
bioinformatics analysis