Evaluating a novel treatment for coronary artery inflammation in acute Kawasaki disease: A Phase I/IIa trial of atorvastatin.
Adriana H TremouletSonia JainJane C BurnsPublished in: Expert opinion on orphan drugs (2015)
The repurposing of well-studied drugs used in the adult population is a cost-effective and efficient strategy to identify new therapies for pediatric diseases. Exploiting the anti-inflammatory, non-lipid-lowering effects of statins may open up new applications for this class of drugs for the pediatric age group.
Keyphrases
- coronary artery
- anti inflammatory
- drug induced
- liver failure
- oxidative stress
- pulmonary artery
- cardiovascular disease
- clinical trial
- minimally invasive
- study protocol
- respiratory failure
- phase iii
- phase ii
- randomized controlled trial
- aortic dissection
- intensive care unit
- fatty acid
- childhood cancer
- mechanical ventilation