Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial.

Gabriel Bastien Christina McAnultyOmar LedjiarM Eugenia SociasBernard Le FollRon LimAhmed N HassanSuzanne BrissetteStéphanie MarsanAnnie TalbotDidier Jutras-Aswadnull null

Published in: Canadian journal of psychiatry. Revue canadienne de psychiatrie (2022)

BUP/NX and methadone showed similar effectiveness in decreasing comorbid depressive symptoms in people with POUD. This effect was partially explained by a reduction in opioid use. As both treatments seem equally effective, clinicians are encouraged to tailor the selection of OAT to patients' needs and characteristics.

Keyphrases

depressive symptoms
end stage renal disease
study protocol
randomized controlled trial
social support
ejection fraction
newly diagnosed
chronic kidney disease
systematic review
prognostic factors
sleep quality
patient reported outcomes
physical activity
patient reported