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Combinatorial fedratinib and venetoclax treatment is effective on human B cell acute lymphoblastic leukemia with high Flt3 expression.

Sean P RinellaHaley C BellDavid P TuricekLei ShiNguyet-Minh HoangLixin RuiNicholas J HessChristian M Capitini
Published in: bioRxiv : the preprint server for biology (2023)
B-ALL in vitro. Gene set enrichment analysis of RNA from B-ALL treated with fedratinib and venetoclax identified dysregulation of pathways associated with apoptosis, DNA repair and proliferation.Combination fedratinib and venetoclax reduces the number of peripheral blood B-ALL blasts in vivo, improving overall survival while also increasing CD19 expression.
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