Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase-Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type.
Jennifer X JiDawn R CochraneBasile Tessier-CloutierShary Yutin ChenGermain HoKhyatiben V PathakIsabel N AlcazarDavid A FarnellSamuel LeungAngela ChengChristine ChowShane ColborneGian Luca NegriFriedrich KommossAnthony KarnezisGregg B MorinJessica N McAlpineC Blake GilksBernard E WeissmanJeffery M TrentLynn HoangPatrick PirrotteYemin WangDavid G HuntsmanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Preclinical in vitro and in vivo studies identified ADI-PEG20 as a potential therapy for patients with rare ovarian cancers, including SCCOHT.