Whole genome analysis of a schistosomiasis-transmitting freshwater snail.
Coen M AdemaLaDeana W HillierCatherine S JonesEric S LokerMatty KnightPatrick MinxGuilherme Corrêa de OliveiraNithya RaghavanAndrew ShedlockLaurence Rodrigues do AmaralHalime D Arican-GoktasJuliana G AssisElio Hideo BabaOlga L BaronChristopher J BayneUtibe Bickham-WrightKyle K BiggarMichael BlouinBryony C BonningChris BotkaJoanna M BridgerKatherine M BuckleySarah K BuddenborgRoberta Lima CaldeiraJulia CarletonOmar S CarvalhoMaria G CastilloIain W ChalmersMikkel ChristensensSandra CliftonCeline CosseauChristine CoustauRichard M CrippsYesid Cuesta-AstrozScott F CumminsLeon di StephanoNathalie DinguirardDavid DuvalScott EmrichCédric FeschotteRene FeyereisenPeter FitzGeraldCatrina FronickLucinda FultonRichard GalinierSandra Grossi GavaMichael GeuszKathrin K GeyerGloria I Giraldo-CalderónMatheus de Souza GomesMichelle A GordyBenjamin GourbalChristoph GrunauPatrick C HaningtonKarl F HoffmannDaniel HughesJudith HumphriesDaniel John JacksonLiana K Jannotti-PassosWander de Jesus JeremiasSusan JoblingBishoy KamelAurélie KapustaSatwant KaurJoris M KoeneAndrea B KohnDan LawsonScott P LawtonDi LiangYanin LimpanontSijun LiuAnne E LockyerTyAnna L LovatoFernanda LudolfVince MagriniDonald P McManusMonica MedinaMilind MisraGuillaume MittaGerald M MkojiMichael J MontagueCesar MontelongoLeonid L MorozMonica C Munoz-TorresUmar NiaziLeslie R NobleFrancislon S OliveiraFabiano S PaisAnthony T PapenfussRob PeaceJaneth J PenaEmmanuel A PilaTitouan QuelaisBrian J RaneyJonathan P RastDavid RollinsonIzinara C RosseBronwyn RotgansEdwin J RoutledgeKathryn M RyanLarissa L S ScholteKenneth B StoreyMartin SwainJacob A TennessenChad TomlinsonDamian L TrujilloEmanuela V VolpiAnthony J WalkerTianfang WangIttiprasert WannapornWesley C WarrenXiao-Jun WuTimothy P YoshinoMohammed YusufSi-Ming ZhangMin ZhaoRichard K WilsonPublished in: Nature communications (2017)
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.