Serum concentration and vascular expression of adiponectin are differentially associated with the diabetic calcifying peripheral arteriopathy.

Carole E AubertSophie LiabeufChloé AmouyalSalim KemelFrédérique Lajat-KissJean-Marc LacorteMarine HalbronAurélie CarlierJoe-Elie SalemChristian Funck-BrentanoLjubica Perisic MaticAnna WitaspPeter StenvinkelFranck PhanZiad A MassyAgnès HartemannOlivier Bourron

Published in: Diabetology & metabolic syndrome (2019)

Peripheral arterial calcification is positively associated with circulating adiponectin levels in patients with type 2 diabetes, but vascular adiponectin expression is already observed at early stages of calcification. Adiponectin secretion could be a compensatory mechanism against the calcification process.Trial registration DIACART NCT number: NCT02431234. Registered 30 April 2015.

Keyphrases

metabolic syndrome
poor prognosis
insulin resistance
chronic kidney disease
type diabetes
clinical trial
binding protein
randomized controlled trial
long non coding rna
chemotherapy induced
open label