Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.
Calvin L ColeJohn F BachmanJian YeJoseph MurphyScott A GerberChristopher A BeckBrendan F BoyceGowrishankar MuthukrishnanJoe V ChakkalakalEdward M SchwarzDavid LinehanPublished in: Journal of cachexia, sarcopenia and muscle (2021)
Together, these findings support a novel model of PDAC-associated SMW and mortality in which systemic inflammation leads to inflammatory cell infiltration into skeletal muscle with up-regulated myocellular lipids.