Unexpected good outcome in severe cerebral fat embolism syndrome.
Bertrand HermannHélène BrissonOlivier LangeronNadya PyatigorskayaJulie PaquereauHélène RobertJohan StenderMarie-Odile HabertLionel NaccacheAntoine MonselPublished in: Annals of clinical and translational neurology (2018)
In this case study, we report the longitudinal and multimodal follow-up of a catastrophic initial presentation of cerebral fat embolism syndrome. We show that despite the initial severity, the cognitive outcome was ultimately very good but with a highly nonlinear time-course and prolonged loss of consciousness (more than 2 months). Repeated clinical assessments and brain-imaging techniques (electroencephalography, event-related potential, 18-Fluoro-Deoxy-Glucose-PET and magnetic resonance imaging) allowed us to monitor and anticipate this dynamic, providing relevant information to guide decision making in front of withdrawal of life-sustaining therapy discussions. This case illustrates the value of multimodal functional imaging in devastating brain injuries.
Keyphrases
- magnetic resonance imaging
- cerebral ischemia
- high resolution
- adipose tissue
- subarachnoid hemorrhage
- positron emission tomography
- case report
- resting state
- white matter
- computed tomography
- pain management
- fatty acid
- functional connectivity
- type diabetes
- pet ct
- stem cells
- brain injury
- early onset
- cross sectional
- magnetic resonance
- blood brain barrier
- metabolic syndrome
- mass spectrometry
- pet imaging
- contrast enhanced
- insulin resistance
- chronic pain
- photodynamic therapy