The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Shunfei YanJiachen XuanNatalie BrajanovskiMadeleine R C TancockPiyush B MadhamshettiwarKaylene J SimpsonSarah L EllisJian KangCarleen CullinaneKaren E SheppardKatherine M HannanRoss D HannanElaine SanijRichard B PearsonKeefe T ChanPublished in: British journal of cancer (2020)
Our findings highlight the possibility of exploiting TOP1 inhibition to be combined with CX-5461 as a non-genotoxic approach in targeting HR-proficient HGSC.